The following agencies are supported by Second Presbyterian Church:
- Advance Memphis
- Calvary Rescue Mission
- Campus Outreach
- Christ Community Health Services
- Christian Educators Association International
- Christian Medical and Dental Association
- Christian Psychological Center
- Church Health Center
- Citizens for Community Values
- Discipling Men, Inc.
- Economic Development Ministries
- Eikon Ministries
- Emmanuel Episcopal Center
- For the Kingdom Camp
- Grace Community Church
- JIFF (formerly Youth for Christ)
- Knightlife
- Life Choices
- Love in Action
- M.A.R.R.S.
- MCUTS
- Memphis Athletic Ministries
- Memphis Leadership Foundation
- Memphis Union Mission
- Mid-South Christian Services
- MIFA
- Multinational Ministries
- Neighborhood Christian Center
- Neighborhood Housing Opportunities
- Neighborhood School
- New Beginnings Community Church
- Olford Ministries International
- Palmer Home for Children
- Redzone Ministries
- Repairing the Breach
- Salvation Army
- Second Chance Prison Ministry
- Service Over Self
- Streets Ministry
- Teen Challenge
- Victims to Victory
- Young Life
- Young Women Striving for Excellence
- Youth Visions


